11月3日，周三拂晓，欧洲冠军联赛小组赛第四轮赛事即将展开，曼联将在他们的主场老特拉福德球场迎战罗马队。
In their previous encounters, Manchester United and AS Roma have faced each other on eight occasions, with the Red Devils holding a slight edge at five wins, one draw, and two losses. Despite AS Roma securing a 3-2 victory in the second leg of the Europa League semi-finals in May 2021, Manchester United ultimately progressed to the next round with an aggregate score of 8-5.
在老特拉福德球场，曼联与罗马的交锋中取得了四场胜利的全胜佳绩，这一成绩同样是他们欧洲主要赛事主场不败的顶级纪录之一，与安德莱赫特的交锋也实现了四战全胜。特别值得一提的是，曼联现任主教练卡里克在球员时期，曾六次在欧冠赛场上遭遇罗马，且在2007年欧冠四分之一决赛次回合，曼联以7-1的比分大胜罗马，卡里克本人更是攻入两球。